GALENOS

28 May. 2025

Associations Between Cardiovascular and Metabolic Factors and Cognitive Functioning in Psychosis

We are examining the relationship between cardiometabolic factors (e.g., hyperglycaemia and body weight) and cognitive outcomes (e.g., executive function and short-term memory) in people with schizophrenia spectrum disorders. Understanding these associations will allow for better clinical guidance and potential psychosocial treatments.

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Cognitive functioning is impaired in individuals with psychosis and accounts for much of the impaired everyday functioning associated with the disorder. Current treatment options are sparse and offer limited benefits. Cardiovascular and metabolic risk factors, such as obesity and diabetes mellitus, play a role in cognitive functioning among general populations and in those with psychosis.

Individuals with psychosis have increased rates of cardiovascular and metabolic risk factors, it is important to examine these individual factors and their association with cognitive functioning to improve our understanding of their role in cognitive impairment and develop psychosocial and pharmacological interventions.